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Tadalafil starts working anywhere from 15 to 45 minutes after you take it. Below, we’ve compared sildenafil (active ingredient in Viagra), vardenafil (active ingredient in Levitra), tadalafil (active ingredient in Cialis) and avanafil (active ingredient in Stendra) to give you a more complete understanding of the most popular medications used today to treat erectile dysfunction. Plus, you may have health concerns that need to be taken into consideration, when prescribing Cialis. In intracavernosal injection therapy, more commonly called penile self-injection, a man injects a small amount of medicine into the side of his penis using a tiny needle and syringe. This allows the penis to fill with blood and stay erect long enough for sexual intercourse. The common PDE5 inhibitor drugs approved in the United States are sildenafil (Viagra), vardenafil (Levitra and Staxyn, the generic form), tadalafil (Cialis), or avanafil (Stendra). An erection usually occurs within 20 minutes. There's not a lot of research about combination treatment for ED, but it's worth talking to your doctor about. The three most popular erectile dysfunction treatments on the market are sildenafil (active ingredient in Viagra), vardenafil (Levitra) and tadalafil (Cialis). They differ in the number of available doses, how quickly they work and last in your system, the dosing, and to some extent in the side effects. Lifestyle changes, including quitting smoking, maintain a healthy weight, eating a healthy diet, and regular exercise, are important in improving erectile dysfunction. The NO stimulates the production of a compound called cGMP, which causes relaxation of the smooth muscle in the blood vessels supplying the corpus cavernosum. Benefits and drawbacks of Cialis